By Jan Vijg
Getting older has lengthy due to the fact been ascribed to the slow accumulation of DNA mutations within the genome of somatic cells. although, it's only lately that the required subtle expertise has been built to start trying out this conception and its outcomes. Vijg seriously stories the idea that of genomic instability as a potential common explanation for getting older within the context of a brand new, holistic figuring out of genome functioning in complicated organisms due to contemporary advances in practical genomics and platforms biology. It offers an updated synthesis of present learn, in addition to a glance forward to the layout of concepts to retard or opposite the deleterious results of getting older. this is often quite vital in a time once we are urgently attempting to resolve the genetic section of aging-related illnesses. furthermore, there's a transforming into public popularity of the crucial of knowing extra concerning the underlying biology of getting older, pushed via carrying on with demographic swap.
Read or Download Aging of the Genome: The Dual Role of DNA in Life and Death PDF
Similar bioinformatics books
This quantity summarizes the hot advancements that made subcellular proteomics a speedily increasing zone. fresh good fortune tales verified that the mix of subcellular prefractionation tools with proteomic research is a really effective method of simplify complicated protein extracts from cells or tissues and to discover low abundance proteins.
Meant as a primer for these simply starting to research nursing informatics, this article both offers an intensive advent to simple phrases and ideas, in addition to an in-depth exploration of the most well-liked purposes in nursing perform, schooling, management and learn. The Third Edition is up to date and improved to mirror the big technological advances completed in health and wellbeing care in recent times.
The luck of individualized medication, complicated plants, and new and sustainable strength assets calls for completely annotated genomic info and the mixing of this data right into a coherent version. an intensive review of this box, Genome Annotation explores computerized genome research and annotation from its origins to the demanding situations of next-generation sequencing facts research.
This ebook constitutes the completely refereed post-conferenceproceedings of the tenth overseas assembly on ComputationalIntelligence tools for Bioinformatics and Biostatistics, CIBB 2013, held in great, France in June 2013. the nineteen revised complete papers awarded have been conscientiously reviewed andselected from 35 submissions.
Extra info for Aging of the Genome: The Dual Role of DNA in Life and Death
For example, the extended longevity in late-reproducing fruit ﬂies mentioned above appeared to be associated with a coordinated upregulation of genes specifying cellular defense mechanisms against free-radical attack. Consequently, these ﬂies showed decreased levels of oxidative damage to proteins and lipids66. In addition, delayed senescence in the long-lived ﬂies was accompanied by reduced fecundity, supporting the idea of a trade-off between reproductive effort and survival (see also below).
Melanogaster, the fruit ﬂy. Clare and Luckinbill61 restricted reproduction of this organism to late age, thereby increasing the intensity of selection during the later portion of the lifespan. They did this for 21–29 generations, at two different THE LOGIC OF AGING 33 larval densities. Populations with high and uncontrolled numbers of competing larvae responded strongly to selection for late-life reproduction, with the length of adult life increasing by as much as 50%. Under such conditions selection produced true-breeding long-lived lines.
For example, while the entire human genome may contain no more than 30 000 genes, there may be three times that many proteins, due to alternative splicing; this is the production of more than one transcript by including or excluding speciﬁc exons (the DNA segments of a gene that are protein-coding; see Chapter 3) or altering the length of a speciﬁc exon. This is without 20 INTRODUCTION taking into account posttranslational modiﬁcation, such as the attachment of phosphate, acetate, lipid, or sugar groups.